I currently have the coordination conditions for make Cu (II) and Zn (II) ions coordinate with a given tripeptide and I'm interested to make them coordinate forming an extended 3D crystalline framework
Cu and Zn readily binds to carboxylate groups, as Cu2 paddlewheel and Zn4O units. You will need a tripeptide with (at least) two free carboxylate groups for coordination. However, I think unless your peptide is very rigid, the structure will be neither crystalline nor stable.
Currently I'm working with a tripeptide with two carboxylates Is that rigid enough or should I change to another peptide?
And my question was rather about the conditions of temperature, pH and the rest
Mr. Ruiz,
There is still uncleasr the effect of MLCT and LMCT on coordination ability, optical and NLO properties. There is possible to have both the effects even in metal-organics with d10 configuration of the metal ion
The synthesis of extended 3D structures in this fashion still relies on a lot of trial and error I'm afraid. What kind of solvents are you using? If you are aiming for a specifific SBU like Cu-paddlewheel/ Zn4O like mentioned above you might consider the literature for conditions in which those have been known to form as the coordination of single metal ions is not going to do it in this case, I think. Furthermore, if you are working with a tripeptide with two terminal carboxylate groups for instance, you essentially have a linear 2-fold node which would really only give you 2D sheets in case of paddlewheels, 3D would only be possible with Zn4O. Also, the remaining N-Donor sites in the peptide might interact with Zn/Cu as well as these are rather soft metals HSAB wise.
You might want to have a look at this article and its references:
Article Synthesis, Structure, Topology and Catalytic Application of ...
Stella Helten: Right now the solvents I've been using are DMF, DEF and distilled water with TRIS buffer adjusted to pH: 8.2. The tripeptide I'm working with has got 2 carboxylate groups as well as the amino groups and a thiol group. On the other hand, How could the source of the ion afect to the coordination? Right now I've only been capable of syntethising the Cu paddlwheel using Copper Acetate as the source. but no other paddlewheel is formed using other metal sources. Also Iom interested on how did you predict if the structure was more likely to be 2D with Cu and 3D only with Zn4O.
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Materials Science
- Materials
- Inorganic Materials