In a number of genome wide studies, Ks and Ka are integral in determining the evolution pressure on the various gene families. In a number of publications online, different authors have employed different bioinformatics tool in calculating Ks and Ka, such as PAL2NAL, SNAP among others. Kindly help in finding the most appropriate tool to carry out this analysis.
Hello,
just like in case of many other genetic parameters there are usually more than one software to choose which can be used for calculations. In our lab we use DnaSP for estimation of Ka and Ks values, but I do not want to say that it is the best software ever :)) It is your decision which soft fits you best or which one gives you more options.
Best wishes
Piotr
Pl see the related link
Article JCoDA: A tool for detecting evolutionary selection
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