Does anybody know a way to calculate J-integral in ANSYS APDL code or MATLAB code?

Hi, How to calculate j integral using the domain integral method in ANSYS code or MATLAB code?

04 February 2021 7,330 3 View

What is the chemical mechanism that allows the solvent N, N Dimethylformamide to dissolve the epoxy resin?

24 September 2020 8,588 3 View

How to choose from which layer to start unfreezing pretrained model?

I'm wondering how you decide on the part of the model to unfreeze. Do you do multiple experiments? Since the use of GPU is expensive, you must have some guidelines. Note: I know the relationship...

09 January 2020 8,069 4 View

DNA extraxtion with SDS/PK/CTAB?

Iwill be so grateful if any researecher can share me protocol of DNA extraxtion using SDS/PK/CTAB method . thanks

29 August 2019 2,025 3 View

How to predict the velocity distribution of a sprayed powder from a nozzle?

Hello everyone, I am searching if it exists any formula used for predicting a velocity distribution of injected solid particles in my case I used flour and the type of injection is through a...

12 June 2019 6,147 3 View

Which flow should I choose in the case of two parallel plates ?

Hello everyone, I am a little confused into choosing the right flow's nature wether it is Laminar or Turbulent and in my case I have the Fluid flow and particles are moving through two parallel...

03 February 2018 5,865 7 View

Does the term of Dynamic Viscosity exist for solid materials?

Hi there everyone ^^, I need some help for my study in the field of Fluid flow, I use COMSOL Multiphysics for this and When I add some solid materials like copper or aluminium for the geometries...

15 December 2016 3,259 15 View

Kindly tell me please what kind of plastic that resists in acetonitrile solvent?

01 December 2016 1,226 6 View

How to simulate Laminar Flow 2D between two horizontal infinite parallel plates ?

19 August 2016 5,872 12 View

Can anyone tell me what is this insect?

I had found on the hare in humid region.

19 March 2015 7,201 21 View

I am interested in medicinal chemistry field, which books are highly recommended to learn from?

I am at the beginner level in drug design and drug discovery, and I am interested to learn more about this field. Which books are highly recommended to start from and gives me all essential...

02 March 2021 8,437 2 View

How to empty large intestine in mice ?

Hi all I am working on colon-targeted drug delivery for which I kept mice fasting for 6h using fasting grills during scotophase (dark period). I observed liquid fecal content in the cecum and...

23 February 2021 7,701 2 View

Can I use a protein-devoid condition as my negative control in ELISA?

Hello, I am running a sandwich-type ELISA where I am trying to inhibit a protein-protein interaction using small molecules. For each experiment, I determine my Z' (Z-prime) to determine the...

23 February 2021 7,429 1 View

How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Which alginate is best for making gel for wound dressing application?

We are looking into utilizing alginate as a gel coating on an HDPE substrate for drug delivery. I would like to ask the community about their experience with alginate and which commercial sources...

15 February 2021 4,319 4 View

Any natural extract (that is easily available) or any drug combination triple which i can use against gram negative?

I'm working on gram negative i want to use any natural extract (plant extract) or triple drug combination against its biofilm formation.

14 February 2021 1,403 3 View

Should the AUC in a concentration-time graph of a subcutaneous implant be roughly the same for poeple?

I have 2 concentration time curves of a subcut drug implant. the first group has a peak around the 50 day mark where as the second group does not. Both groups received the same implant by the same...

10 February 2021 2,305 3 View

XRPD Quantification - Building a calibration curve of drug excipient?

I am aiming to utilise XRPD to quantify a drug excipient within a drug product and have been having a little trouble building the calibration curve to allow for this quantification up until this...

10 February 2021 6,145 3 View

Is this grounds for theophylline toxicity even though her plasma is within the therapeutic range? if it is, how is that possible?

A patient was given 300 mg Theophylline taken twice a day for the treatment of her bronchial asthma and has a positive clinical response. She has been compliant in taking her medication however,...

09 February 2021 3,489 3 View