Future of iron oxide nanoparticles in the biomedical fields?

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Charan Thej

Dear Purva,

SPIONS or superparamagnetic iron oxide nanoparticles are widely used now to label stem cells and track their biodistribution with MRI.Mesenchymal stem cells especially are being tagged and tracked for therapeutic effects in various disease indications.

Here is a reference example..

http://stemcellres.com/content/4/5/126

All the best!

Orazio Vittorio

Hi Purva,

in the past I worked with stem MSCs and IONPs for two main applications:

1) Try to guide magnetically these cells to the target organ for transplantion and Truck them

2)Stimulate these cells to diffrentiate by mechanical induction generated by magnetic force.

Of course you have to find to functionalize the IONPs in oder to increase the interaction and the stability in the cells. But you have to avoid toxicological effects. Now I am using IONPs for drug delivery in cancer.

Good luck

Dr.Purva Sanganeria Sethi

Dear Orazio Vittorio

Thanks for those wonderful suggestions.........

i have already optimized my particles under the criteria of toxicity and colloidal stability and getting reproducible results too.

Are your first and second point related to Magnetophoresis, as now a days much work is going on in this particular area

it would be great if i can get some information on external mechanical stimuli apart from using a magnet of some threshold to direct the particles in vivo

Thanks for the help

what are the views and suggestions in the area of using IONPs for invivo labeling and tracking of stem cells ?

Patitapabana Parida

What are the evaluation stages of non-biodegradable coated Fe2O3 nano-particles for MRI. Kindly make suggestions.

Dear Patitapabana Parida,

Your question is not clear to me .

do you want to know about the characterization techniques used for synthesized iron oxide nanoparticles ?

Dear dr. Purva sanganeria

i was able to formulate polymer coated iron nano particle for mri.

I want to know about the characterisation techniques for the same. Please suggest me as soon as possible.

Best regards