The main problem is the dimension of a rat molar. To design an experiment for furcation repair, first you need to induce furcal perforations. Even with the use of a surgical operating microscope, it will be extremely difficult to standardise the size and location of the perforations, which jeopardises validity of the study. Also, to access and repair those perforations you would probably need to damage the tooth crown dramatically and leakage would be almost impossible to control.

Animal models to study furcation repair usually involve miniature pig teeth or dog teeth...to the best of my knowledge.

Thanks a lot

Hi Fayez Hussian Niazi.

The work in rats is fascinating, and just as Dr. João Miguel Marques dos Santos already mentioned, it is extremely difficult to standardize the size and location of the perforations, but that is what makes it more interesting and valuable when you do it. Then, I think that it is why there are not so many investigations done in rat furcation.

Some years ago, during my master's research project, I worked on several models in rat teeth, and one of them was precisely in furca. Many exciting things came out, and I am sure that it is possible to use the model. Unfortunately I left the area during my Ph.D. and now, at the university where I am currently working I do not have access to bioterium animals, but I will definitely return to the subject at some point and return to work with rat molar teeth and histology.

I have two small reports of my work for those years (when I was a student), here I leave the link and my email in case I can help you. I know perfectly well that when wanting to work in this area it is difficult to find researchers who can give you their experience. Here, you have now two who can help you with this fascinating model. Regards Ruben

[email protected]

https://www.researchgate.net/publication/320727767_Evaluacion_de_un_modelo_experimental_en_molares_de_rata_para_pruebas_de_biocompatibilidad

https://www.researchgate.net/publication/319831495_Bone_resorption_in_an_experimental_model_for_assessing_of_endodontic_cements_in_the_furcation_area_of_rat_molar_teeth_Resorcion_osea_en_un_modelo_experimental_para_eva-luacion_de_cementos_endodonticos

Thanks a million for such a wonderful and helpful reply

Dear Sir, can i have an English version of these two precious articles of yours.

I am sorry, I currently do not have those papers in English, I hope in a few months to publish a small report in English, for now, I offer you that if you require any specific information you ask me, and I give you the details.

Thanks for your interest

Ok i will come back to you soon...thanks

Dear Fayaz,

See the article for a reference

Article An In vitro Comparison of Furcal Perforation Repaired with P...

file:///C:/Users/3020/Cookies/Desktop/Downloads/Rat_molar_teeth_as_a_study_model_for_direct_pulp_c.pdf

Hope it is helpful for you.

Ashish

Hi I didn’t see any study about repairing furcation on rats but it is possible because to try repairing with mineral trioxide aggregateother stidies intraosseous or subcutanuous are possible and it is very good to do o

I am trying to tell you that it is important to do it with MTA to repair the furcation on rats

Very important article

Use of mineral trioxide aggregate for repair of furcal perforations.

T R Ford, Mahmoud Torabinejad, +2 authors S P Kariyawasam

Periradicular inflammatory response, bone resorption, and cementum repair after sealing of furcation perforation with mineral trioxide aggregate (MTA Angelus™) or Biodentine™

Magda de Sousa Reis, Roberta Kochenborger Scarparo, […]José Antônio Poli de Figueiredo

Clinical Oral Investigations volume 23, pages4019–4027(2019)Cite this article

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thanks a million

thanks