I am trying to make a formula for:
A- Fosfomycin disodium 20% oral solution
and
B- Fosfomycin disodium 20% and tylosin tartrate 5.0 % oral solution
but I am facing many difficulties:
1- Fosfomycin Disodium is insoluble in organic solvents (Ethanol, PG, PEG and N-methyl pyrrolidone)
2- When mixing tylosin aqueous solution with Fosfomycin disodium aqueous solution, a precipitate forms, which is not soluble
3- When I tried to adjust the pH for the solution to 5-6 , the Fosfomycin reacts with the acid with effervescence
Can any one help with any idea
A stable oral solution containing 20% Fosfomycin Disodium and 5% Tylosin can be formulated by first dissolving the powders in purified water. To overcome stability and palatability challenges, key excipients must be added: glycerin and propylene glycol act as co-solvents and stabilizers, a high-potency flavor mask (e.g., anise) is essential to counteract Tylosin's extreme bitterness, and a preservative (e.g., methylparaben) is required for multi-dose use.
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