For genetic associations with schizophrenia cognitive deficits, is it better to examine the association to a selected SNP or to a set of SNPs?

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Hanif G Khalak

Sets of SNPs - given the complexity of cognitive phenotypes, and results from GWA studies performed for schizophrenia, individual SNPs are unlikely to usefully explain disease burden and functional correlations.

Joelle Choueiry

Thanks Mr. Khalak for the reply, are there any good references that you might suggest?

Himanshu Chheda

Why don't you look at this paper: http://www.ncbi.nlm.nih.gov/pubmed/24463508

Although it doesn't talk about a set of SNPs, it does talk about gene-sets.

Good luck!