For cell experiments, is the lipid-soluble form used? Is phosphate water-soluble?

07 August 2025 1 9K Report

Hello everyone, I’ve recently been using Ruxolitinib (HY-50856, MCE) for cell experiments. Is this compound lipid-soluble or water-soluble?

Lily Watson

Hi, You can prepare stock solutions using DMSO. According to MedChemExpress (MCE) testing, the solubility of Ruxolitinib (HY-50856, MCE) in DMSO is at least 100 mg/mL (326.40 mM). Please use freshly opened DMSO to ensure quality. https://www.medchemexpress.com/Ruxolitinib.html

Generally, DMSO has antimicrobial properties, so filtration for sterilization is not necessary after dissolution. When using, dilute directly with culture medium or buffer to the desired working concentration.

The answer to this question comes from MedChemExpress Technical Support. [email protected]

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