If we want to block the MAPK pathway (ERK, P38), which of the downstream genes' expression are important for evaluations of changes in the MAPK pathway?
The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that mediate intracellular signaling associated with a variety of cellular activities including cell proliferation, differentiation, survival, death, and transformation.These signaling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. For downstream genes' expression are important for evaluations of changes in the MAPK pathway p38 gene signaling pathways. other gene expressions are TDP-43, TAR DNA-binding protein gene, amyloid precursor protein and transcription factors such as Elk-1, c-Jun, ATF2.
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