Hi Ahmed

There are lots of regimens that can cause severe neutropenia (with the risk of neutropenic sepsis). For instance, chemotherapy schedules used for acute leukaemias (both myeloid and lymphoid) can cause severe neutropenia in almost 100% of the cases (eg. daunorubicin-cytosine arabinocide, high dose Ara C, MAZE, FLAG-Ida, Clofarabine etc). Fludarabine-Cyclophosphamide-Rituximab combination used for chronic lymphocytic leukaemia also can cause severe neutropenia in >20% of the cases. Several schedules used for lymphoma also can cause neutropenia in high proportion of the cases (eg. CHOEP used for T-NHL, R-DA-EPOCH for high grade NHL, BEACOPP for Hodgkin's disease, CODOX-M/IVAC for Burkitt's lymphoma, Hyper CVAD for mantle cell lymphoma to name a few). Of the myeloma regimens, melphalan containing schedules are myelosuppressive. I am sure there are several regimens used in solid tumours are also associated with high risk if neutropenia.

Best wishes

Siva

In our manuscript we report which were the main chemotherapeutic schemes associated with febrile neutropenia in Colombia, document annex.

Article Febrile neutropenia in patients with hematological malignanc...

In our manuscript, we describe the main schemes that caused neutropenia in our population.

Article Febrile neutropenia in patients with hematological malignanc...