Emulsion formulation of a drug could evaporate under accelerated stability conditions. Therefore the obtained assay data at different time points would be from a concentrated emulsion. Sealing the container could be a solution, but the head space in the container could accommodate the evaporated solvent. Is there a way to store emulsions to avoid this? Or is there any specific way of sampling?
Dear Sravan,
the problem with evaporation is due to vapor pressure inside the container is higher than outside. Therefore one solution beside absolute sealing is to put it in an atmosphere saturated with the evaporating solvent, in your case likely water. Storing the container in another container with some drops of water might be easier than saturate the air in the oven.
Thank you Dr. Sobisch for your answer. By putting few drops of water in the secondary container, I believe the air would attain equilibrium leading to no evaporation! That is a very good idea. Thanks again.
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