have read about bioactive peptides in food with potential health benefits and much research in this area but also have seen references to a RICE peptide=RGD--that has embryotoxicity at least in lab animals. This RGD is described as a LAMININ-like peptide involved in immune mediated reproductive failure. I am also aware of reports of anti-LAMININ antibodies found in women with endometriosis and infertility. Is there any evidence of this RGD embryotoxicity in humans, or any cross reactivity beween the RICE RGD and HUMAN LAMININ---I am totally unaware of any dietary implications related to RICE on pregnancy---any data at all in this context?
The value of physiologically and biologically active motifs present in proteins
is considered critically taking into attention many aspects including the mechanisms
of action of the peptide in a body, the processes of protein hydrolysis and the inhibition of them during enzymatic digestion, the absorption of peptides into a bloodstream, the length and a structure of the peptide. Although the enormous growth on studies concerning the structure and the activity of the motives had been observed, some mechanisms of bioactivities of peptides are still not fully discovered. However, the information concerning the function and structure of bioactive proteins and peptides gathered in the various database resources interconnected with the mathematical descriptions of the biological phenomena is a powerful tool to assign the protein to a group of more potent biomacromolecules. BIOPEP is one of the tools which contributes to such approach.
The strategy of analysis of proteins as the precursors of bioactive peptides involving
BIOPEP procedure enables to classify proteins to be a rich/poor source of motifs with biological and physiological functions..This approach can be successfully
applied to introduce nutraceuticals as the valuable source of peptides with biological
activities.