In my opinion, there is no perfect formula for any clinical situation. MDRD is good for GFR 60 ml. Cystatin C is not influenced by age, sex, muscle mass... but is more expensive. The formula based on creatinine and cystatin (Lesley A et al, N Engl J Med, 2012, 367:1, 20-9) seems even better
All eGFR calculations have limitations and I agree with Gillain-Martin that there is no perfect formula. CKD-EPI has improved compared to MDRD but is cumbersome to apply in clinical practice and has not been implemented as a screening tool because of its complexity. Especially these formulas underestimate kidney function in healthy elderly individuals. In otherwise healthy individuals Rule's Quadaritic formula is better as this was validated in tranplant donors, who did not have kidney disease.
we are doing cystatin C and Sr.Creatinine ,both everyday when a patients come for a renal profile.
but why am asking is for to do research purpose,when i search some of the published articles,they all calculated both MDRD and CKD-EPI.and also they compared these both calculations.we can find some differences between these both calculations.no accuracy. when we do research in this topic...like CKD.,why we cant be able to get a net or accurate reports..thats why i'm trying do or get some valuable or modification is there any to measure and prevent or to give some precautions to the patients.