Dear Jona, 

here is something about adherence to Noac's therapy: 

http://www.medscape.org/viewarticle/852478_transcript

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Guidance and counseling can be the more effective Educational therapy for this. I am not saying that it is Educational material but a strategy have.And follow-up is a powerful material with researchers.

You can also check the following links-

https://www.escardio.org/static_file/Escardio/Subspecialty/EHRA/Publications/NOAC/slide-set-noac.pdf

http://www.medscape.org/viewarticle/812941_transcript_2

http://www.medscape.com/viewarticle/843102

Thank you for the answer's!!!

The therapist must use his moral, scientific and technical authority to get the appropriate and necessary effects, and, if this is not sufficient to achieve the positive effects, should resort to the current laws or regulations in the country.