Piroxicam ( zwitterionic forms) interact with two ionic surfactants SDS/CPB? possibility of interaction ?
Methylene blue ( cationic form) interact two ionic surfactants anionic and cationic surfactant? Possibility of interaction?
Prakash Karunanithi
It is believed that the interaction of the dye, drug and surfactant occurs due to hydrophobic interaction. Modern research shows that it has a quantum nature with the participation of the Nuclear quantum effect.
Thesis Mirgorod Yuri. QUANTUM NUCLEAR EFFECT IN AQUEOUS IONIC SURFA...
Thesis Mirgorod Yuri. QUANTUM NUCLEAR EFFECT IN AQUEOUS IONIC SURFA...
The Piroxicam molecule has practically no charge in water, therefore, the solubilization in L-81 (nonionic surfactant) and SDS (anionic surfactant) micelles is due, as Mirgorod pointed out, mainly due to hydrophobic interaction, which can be supplemented by the formation of an H-bond with oxygen included in surfactant molecules, especially L-81. Both types of interaction do not lead to significant changes in the electronic spectrum, which was observed by the author. I do not agree that the band with a maximum of 353 nm refers to the n-pi transition, this is a pi-pi transition, since the bands of the n-pi transition are 100-1000 times less intense. The methylene blue molecule has a cationic charge and, upon interaction with the SDS micelle, an electrostatic interaction will appear, which will lead to a change in the electronic spectrum of the dye both due to this effect and a shift in the dye monomer-dimer equilibrium.
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