I have synthesised a compound which is inhibiting the enzyme at higher concentration of 150 microgram per ml (IC50=150 microgram) but not cytotoxic to cells even above 1000 microgram per ml can that a potent drug molecule?
Hello, yes it can be drag after at least 10 year after preclinical and clinical experiments and also all depends from mechanism of inhibition and side effects.
Hello, yes it can be drag after at least 10 year after preclinical and clinical experiments and also all depends from mechanism of inhibition and side effects.
What matters is not the IC50, but whether an effective concentration can be achieved for a sufficient period of time at the site of action with a reasonable-sized dose and without severe side effects.
Thank you for your nice work, but the inhibitory effect of specific enzyme selective or no involves invivo or invitro and the conversation of a chemical compound with specific therapeutic action into drug required full data about pharamaco kinetics and dynamics as well as clinical research and toxicology analysis
For reasons given above, there are are many drug lead compounds and few actual approved drugs. Sorry for being discouraging. Drug discovery and development can be very costly.
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