The hydroxyapatite is a wide-recognized biocompatible material. The polymer matrix you noted (HA-LLDPE)  is used as a biocompatible material too, mainly, for endoprotheses making. As your question, we were studying  the opportunity of LLDPE application in heart valve as a reinforcing filler because of leaflets of artificial heart valve of design proposed should be made from relatively elastic material such as polyurethane (see, please, the papers "Strain-strength Characteristics of the Polymer Heart Valve Prosthesis // Russian Journal of Biomechanics.– 2006.– Vol.10, №.4.– P. 47-55"; "Nano- and Micro-Structured UHMWPE Composites Filled With Hydroxyapatite Irradiated by Nitrogen Ion Beams for Bio-Medical Applications // Russian Physics Journal. – 2014. – Vol. 56, № 10. – P. 1137–1143".

I think, the hydroxyapatite one can assume as a filler component of polymer composite heart because of capsulation in polymer matrix. But this conclusion should be approved by corresponding biological tests only.

Best regards    

Dear Serge

Thanks for the prompt response.

My question is regarding, the leaching of HA from the matrix leading to mineralisation onto the walls, thereby causing calcification.

Dear RG colleagues,

I am fully agree with Dr. Serge.

Regards, Emad