The term "TSA Software" is not specific enough to provide a definitive answer, as there are multiple software programs with similar abbreviations. However, assuming you are referring to the "Trial Sequential Analysis" (TSA) software, commonly used for meta-analyses in clinical research, I can provide some information.

TSA software, such as the TSA program developed by the Copenhagen Trial Unit, is primarily designed for conducting trial sequential analyses in meta-analyses. Trial sequential analysis is a statistical method that aims to determine the optimal sample size required to draw reliable conclusions from accumulated data in meta-analyses, while considering the risks of random errors and false-positive results.

Hazard ratios (HRs) are commonly used in survival analysis, particularly in studies involving time-to-event outcomes. While TSA software is primarily focused on calculating cumulative Z-curves and monitoring boundaries for meta-analyses, it may not specifically include tools for directly analyzing hazard ratios. TSA software typically deals with binary outcome data or event rates rather than survival data.

If you specifically need to work with hazard ratios, it would be more appropriate to use specialized survival analysis software, such as R packages like "survival" or "rms," or commercial software like SAS or SPSS. These software options provide dedicated functions and tools for performing survival analysis, including the estimation and interpretation of hazard ratios.

It's important to choose the appropriate software based on the specific analysis you require and the type of data you are working with to ensure accurate and reliable results.