Does the presence of prim. amines interfer with the reaction of an alcohol with a sugar-trichloroacetimidate?

06 June 2016 1 7K Report

Hi,

I'd like to react 2-aminoethanol with a Bn-protected glucose trichloroacetimidate and I'm wondering whether the amine will interfer with the glycosylation.

Cheers

Andreas

Talaat I. El-Emary

Dear Andreas Beil I agree with Dr. Larissa Krasnova.You its better to mask the amino group with azide,run glycosylation and then reduce N3 to NH2.

Good luck

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Science method

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