I am doing a study of the disposition of a drug, but I use animals anesthetized with Urethane, when analyzing the data I saw that the elimination is very impaired when the mouse is anesthetized if compared to the non anesthetized. Anyone have any explanation?
Check the following reference
https://www.ncbi.nlm.nih.gov/pubmed/7746831
The anesthetics tested were fentanyl citrate, alpha-chloralose, ketamine, urethane (ethyl carbamate), halothane, and ether. CO2 anesthesia was used as the control comparator. Theophylline was used as a probe for CYP1A activity, phenobarbital for CYP2B/2C, flecainide for CYP2D1, and ethosuximide for CYP3A activity. All probes were administered via tail vein injection after anesthetic-induced loss of the righting reflex.
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