Does someone have the actual reference for the claim that "most serotonin is found outside the CNS"?

Dear Megha PB

Pls. find the attached files

https://www.hindawi.com/journals/tswj/2012/823493/

page 79 in: Kathleen Marion Brophy, Heather Scarlett-Ferguson, Karen S. Webber, Anne Collins Abrams, Carol Barnett Lammon. 2010. Clinical Drug Therapy for Canadian Practice Lippincott Williams & Wilkins, Pp.1120. ISBN1605475173, 9781605475172

http://www.koreamed.org/SearchBasic.php?RID=0042KJP/2012.23.2.45&DT=1

http://www.annualreviews.org/doi/abs/10.1146/annurev.med.60.042307.110802?journalCode=med

https://www.researchgate.net/publication/26693775_The_Expanded_Biology_of_Serotonin

https://ucdavis.pure.elsevier.com/en/publications/the-expanded-biology-of-serotonin

https://www.ncbi.nlm.nih.gov/pubmed/19630576

Bjorklund, T. Hokfelt, L.W. Swanson. 1996. Integrated Systems of the CNS, Part III: Cerebellum, Basal Ganglia, Olfactory System Elsevier,Pp.583. ISBN 0080534821, 9780080534824

Hoyle Leigh, Jon Streltzer. 2014. Handbook of Consultation-Liaison Psychiatry Springer,Pp.561. ISBN3319110055, 9783319110059

Lewis Mander, Hung-Wen Liu 2010.Comprehensive Natural Products II: Chemistry and Biology Newnes,Pp.7388. ISBN0080453821, 9780080453828

http://www.nature.com/mp/journal/v11/n8/full/4001837a.html

http://biology.kenyon.edu/BMB/jsmol2013/JCJK/index.html

Hoping this will be helpful

Regards

Prof. Houda Kawas

Article The Expanded Biology of Serotonin

Megha PB

Dear Prof Houda,

Thank you so much for the references.

I should have framed my question better, actually. What I meant to ask is if there is a reference to support the claim 'Most serotonin is found outside the body"?, i.e, if there is a publication which reports this?

Mostly, people refer to this review while making the statement but having checked for the references in this review, I couldn't find any.

I would really appreciate your help on this.

Thanks and regards,

Megha

Zahir Hussain

Hi Megha:

Please read the following review:

Cirillo C, Vanden Berghe P, Tack J. Role of serotonin in gastrointestinal physiology and pathology. Minerva Endocrinol. 2011 Dec;36(4):311-24.

My suggestion is that for detailed information about Serotonin, read The Medical Biochemistry Page By King MW Indiana University School of Medicine in below given link. You will get diverse information in this link page about what you need to know that most serotonin is found in gastrointestinal tract where it controls intestinal movements.

https://cse.google.com.sa/cse?cx=partner-pub-0170489783089944:7561872190&ie=UTF-8&q=serotonin&sa=Search&ref=&gws_rd=cr&ei=nxsqWIvFMYTzaKSClsAL#gsc.tab=0&gsc.q=serotonin&gsc.page=1

Best wishes

Prof. Zahir

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