Does SEM show difference between peptide conjugated and unconjugated PLGA nanoparticles?

11 July 2017 1 7K Report

If these are SEM images for one PLGA nanoparticles formulation before and after peptide conjugation by EDC, can I tell if the blebs on the conjugated nanoparticle are attributed to the conjugated peptide?

What confirmatory tests should I perform? NMR or TEM or something else?

Vinod Kumar

Dear Aya Ahmad,

I think you should perform SEM for only peptides and EDC+PLGA also.By which you can compare that the blebs are peptides not EDC.You can perform HRTEM for confirmation.

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