Google scholar search found quite a few reports of efficacy in toohpaste/ dentifrice context. Saw noithing re mouthwash.

Chlorhexidine is not mean to be a permanent consumer mouthwash product - tooth staining a a major issue.

Thanks for responding, Phil,

I'd already checked out what was available via google-scholar (mostly GSK sponsored and no direct comparisons of chlorhexidine and o-cymen-5-ol), before asking on ResearchGate.

Appreciate the point about tooth staining, but I've only seen that as a problem with the much stronger gel products, e.g. Corsodyl Gel 1% w/w.

Regards - Paul

Peridex @ 0.16% stained

Interesting. But at least it does seem to wash off in time.

I'd not be too cavalier about it. Staining can certainly persist and much too long for any consumer wondering at the "benefit".

Thank you.

The antiseptic efficacy between CHX and o-cymen-5-ol has been compared in vitro. Due to the anionic character of cymenol, it penetrates deeper into the biofilm and achieves similar and in some cases higher bacterial lethality rates than CHX. Another point to note in the clinic is that it is not advisable to use CHX for long periods of time due to its staining effect, however oral care products with cymenol can be used daily and long term.

Note if you want to increase the effectiveness of cymenol it is highly recommended to formulate it with zinc salts.

Translated with www.DeepL.com/Translator (free version)

Many thanks, Javier. That is helpful, and for the translator link too. Paul