Hello,
Please help me know if the platelet size is bigger. Does it mean it has more growth factors or more microtubules within it?
Asghar Mohammadzadeasl While large platelets are haemostatically more active than smaller platelets and may be more important functionally than smaller platelets, it hasn't been thoroughly investigated for effects on Growth factors. Most studies in platelet enriched plasma found variable effects of number on GF levels (reviewed in PMID: 29337592). In another review however PC and MPV are suggested to be considered together ( Article Mean Platelet Volume (MPV): New Perspectives for an Old Mark...
) hope this clarifies the current status on this subject.
Rabeah Al-Temaimi Thanks a lot
what is the role of the size of the platelet?
Which one is more important, the number of platelets or the size when it comes to causing cell proliferation?
Daer Asghar!
Please you look at this article:
Article Does size matter in platelet production?
The microtubule cytoskeleton
PLT shape and integrity are maintained by a well-defined and highly specialized cytoskeleton composed of an intricate system of molecular struts and girders that also regulate PLT size. Likewise, released PLTs contain 10- to 20-fold increased numbers of peripheral microtubule coils, relative to normal controls, that are often organized like balls of yarn rather than rings, which may explain why the majority of these cells have a spherical rather than the discoid form. The inability to further constrict proPLT tips before abscission resulting from bending energies determined by the cortical microtubule band could account for the increase in terminal PLT size.
Hello Asghar Mohammadzadeasl as Alexandr Chernov mentioned and referenced an excellent review that should help you understand the role of platelet size and the effects of megakaryocyte proliferation and impact on platelet maturation, fusion and fission.
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