Do all viral infections generate a response leading to p53 causing apoptosis?
The induction of apoptotic cell death is a hallmark of most virus infection. Although a variety of cellular and viral proteins have been implicated in this process, to date poor conserved cellular pathway has been identified.
The tumor suppressor protein p53 is essential for the induction of cell death especially in influenza virus-infected cells. In primary human lung cells, influenza virus increased p53 protein levels. This was also noted in the human lung cell line A549, along with the up-regulation of p53-dependent gene transcription. Reduction of p53 activity in A549 cells inhibited influenza virus-induced cell death. TQ
Not all viral infections generate a response leading to p53-mediated apoptosis. Only in certain cases when viral infections result in an innate immune response that leads to cell death. Whether cell undergoes cell death following a viral infection in p53-dependent manner or not may depend upon the cell type and the infecting virus. In general, a DNA virus infection of myeloid cells leads to cell death.
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