Does neuroinflammation and neurodegeneration induced by continuous infusion (intracerebroventricular) of LPS occur in all CNS neurons or only in specific regions? The literature is rich in research about the hippocampus, but not on other regions. I have special interest in the hypothalamus.
As you know LPS mediated inflammation is closely associated with nitric oxide production and up regulation of iNOS production at most sites all of which has considerable publications documenting LPS effect on inflammation. Other mediators also play a role. Systemic administration of LPS also produces change in the Nucleus Tractus Solitarii. There is a lot of literature supporting communication pathways between the immune system and brain. I have attached one for your consideration. You are treading on unknown territory as best I know and very interesting work, I look forward to hearing more.
Dear Frank,
Thank you for the article, it is great.
I'm interested to know how neurons in the hypothalamus will react with and without administration of drugs with anti-inflammatory potential. But for this, I need to know how the hypothalamus will react to this model of inflammation (continuous infusion of LPS).
Soon as I have some answer, I'll tell you more!
Thank you!
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