I am looking for models to induce hypothalamic inflammation in mice.
The most common model is through high-fat diet administration, but I'm looking for something related to TNF-alpha or other cytokines (intracerebroventricular).
Does anyone know or have used another induction model?
Dear colleague,
maybe treatment with monosodium glutamate (MSG) can induce hypothalamic lesions via inflammation. However, I had no experience with this model.
That's what I'm looking for, but I'm not finding a protocol with infusion of TNF-alpha related with hypothalamic inflammation.
Do you have any experience with this?
Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?Joshua P. Thaler , Stephan J. Guyenet , Mauricio D. Dorfman , Brent E. Wisse et Michael W. Schwartz ⇑
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