Epidemiological and experimental evidence suggests it does. Lead exposure has been associated to hypertension and peripheral disease. In fact, it is able to induce vasoconstriction mediated by the alpha adenoreceptor.

Hi Jose, do have by any chance a paper with studies in humans about this subject?

Hi Leonardo This are some studies related to the subject I hope they can guide you in your search of this intetesting topic in the literature.

JAMA. 2003 Mar 26;289(12):1523-32.

Blood lead, blood pressure, and hypertension in perimenopausal and postmenopausal women. Nash D, Magder L, Lustberg M, Sherwin RW, Rubin RJ, Kaufmann RB, Silbergeld EK

Environ Health Perspect. 1991 Feb;91:71-5.

Lead, blood pressure, and cardiovascular disease in men and women.

Schwartz J..

Toxicol Appl Pharmacol. 2010 Nov 15;249(1):41-6. doi: 10.1016/j.taap.2010.08.012.

The relationship between occupational exposure to lead and manifestation of cardiovascular complications in persons with arterial hypertension.

Poręba R, Gać P, Poręba M, Andrzejak R.

Hi, I think the following references can resolve the question:

Pirkle J. L. et al. The relationship between blood lead levels and blood pressure and its cardiovascular risk implications //American journal of epidemiology. – 1985. – Т. 121. – №. 2. – С. 246-258.

Navas-Acien A. et al. Lead exposure and cardiovascular disease—a systematic review //Environmental health perspectives. – 2007. – Т. 115. – №. 3. – С. 472.

Schwartz J. Lead, blood pressure, and cardiovascular disease in men and women //Environmental health perspectives. – 1991. – Т. 91. – С. 71.

Fewtrell L. J. et al. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure //Environmental Research. – 2004. – Т. 94. – №. 2. – С. 120-133.

Kopp S. J., Barron J. T., Tow J. P. Cardiovascular actions of lead and relationship to hypertension: a review //Environmental Health Perspectives. – 1988. – Т. 78. – С. 91.

Møller L., Kristensen T. S. Blood lead as a cardiovascular risk factor //American journal of epidemiology. – 1992. – Т. 136. – №. 9. – С. 1091-1100.

Kirkby H., Gyntelberg F. Blood pressure and other cardiovascular risk factors of long-term exposure to lead //Scandinavian journal of work, environment & health. – 1985. – С. 15-19.

Vaziri N. D. Mechanisms of lead-induced hypertension and cardiovascular disease //American Journal of Physiology-Heart and Circulatory Physiology. – 2008. – Т. 295. – №. 2. – С. H454-H465.

Ademuyiwa O. et al. Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria //Lipids in health and disease. – 2005. – Т. 4. – №. 1. – С. 19.

Gump B. B. et al. Prenatal and early childhood blood lead levels and cardiovascular functioning in 9½ year old children //Neurotoxicology and teratology. – 2005. – Т. 27. – №. 4. – С. 655-665.

Best wishes,

Alexey

Lead has been shown to have effects on haemoglobin synthesis and anaemia

has been observed in children at lead blood levels above 40 µg/dl.

Lead exposure is associated with a small increase in blood pressure. There are few evidences suggesting that any association of lead blood levels with blood pressure is of major health importance. I'll be glad to be updated if this is not accurate.

Thank you all for the help. I really appreciate that.

Lead affects the cardiovascular system mainly by changing the peripheral autonomic nervous system and leading to chronic neuropathy. Chronic exposure, even to low doses of lead, can impair conduction in myocardium.

Article [Effect of lead on the cardiovascular system]

Please also go through the following RG links.

Article Lead Exposure and Cardiovascular Disease—A Systematic Review

Article Cardiovascular effects of lead exposure

Article Lead poisoning: acute exposure of the heart to lead ions pro...

Article Mechanisms and toxic effects of lead on the cardiovascular system