It is well known that STATIN can block the enzyme HMG CoA Reductase which make cholesterol in the liver. Henceforth, LDL level gets decrease and HDL increases.
Applying the same concept, when a particular phytomedicine reduced Total Cholesterol (TC) and LDL (Bad Cholesterol) level significantly, Is it convincing to assume that same phytocompound simultaneously can increase HDL (Good Cholesterol) level?
I have found Bergamot clinically effective. See portion of relevant article below which may be relevant:
In vivo studies have reported that oral administration of bergamot juice can reduce blood cholesterol and improve the atherogenic index in mice. Hand pressed bergamot juice was administered to Wistar rats weighing 180 to 200 grams while being administered a high cholesterol diet [28]. The animal feed included cholesterol, 2%; sodium cholate, 2%; vitamin mixture, 2%; oligoelements, 0.2%; salt mixture, 5.8%; coconut oil, 20%; cellulose, 4%; sucrose, 44%; casein, 5%; drakettprotein, 15%. Animals were divided into three groups as follows: 1) normolipidemic control rats on a standard diet 2) hypercholesterolemic diet for 30 days and 3) hypercholesterolemic diet for 30 days receiving 1 mL of bergamot juice daily for 30 days. The main flavonoids identified in the present study were 1) neoeriocitrin (370 ppm), 2) naringin (520 ppm), and 3) neohesperidin (310 ppm). Bergamot juice was found to reduce cholesterol (29.27%), triglycerides (46.12%), and LDL (51.72%) and an increase in HDL (27.61%) levels versus hypercholesterolemic controls. The atherogenic index was 1.09 ± 0.10 in the C. bergamia-treated group as compared with 3.09 ± 0.20 in the hypercholesterolemic group.
https://www.ncbi.nlm.nih.gov › pmc › articles › PMC6497409
by MC Nauman - 2019 - Related articles
https://www.researchgate.net/publication/5946836_HDL_Cholesterol_Very_Low_Levels_of_LDL_Cholesterol_and_Cardiovascular_Events