Dear all,
Does anyone know why the isoflurane concentration ug/mL of artery and vein aren't the same under equilibrium state?
Can someone advise further please.
Many thanks for attention.
Dear Ka,
As you indicated, isoflurane concentration in artery and vein are under equilibrium state. This means that
P1.V1. in artery = P2. V2. in vein (gas laws); since the value of V in the artery is different than the value of V in the vein, P iso in the vien will be different than P iso in the artery and hence the concentration.
Hoping this will be helpful,
Rafik
Hi Rafik.
Thank you so much for your comment.
P1V1 artery = P2 V2 vein (may i know how is concentration ug/ml being related?)
How should I explain the differences of isoflurane concentraiton between artery and vein?
many thanks.
Dear Ka,
P1V1=P2V2== nRT; n is number of moles; R is the gas constant and T is the temperature (constant; 37 C).
Since n should be the same in vein and artery and the concentration is equal to n/V (number of moles/volume); and v in the vein is different from v in the artery accordingly the concentration will be different in vein and artery.
Rafik
Dear Rafik,
I am trying summarise it again in the attached file. Please correct me if i was wrong.
Many thanks.
Dear Ka,
The blood volume (v) in vein is less than in artery and since n is equal in both; n/v will be different. RT always constant.
Rafik
Thank you so much Rafik!
Have a great Christmas and Happy new Year everyone.
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