I want to perform experiments with animal model of mitochondrial dysfunction in lung. I have seen a variety of OXPHOS defect models for other organs (heart, skeletal muscle, liver, brain etc.) but have not been able to find any specific model for lung. I wonder whether these models also feasible to be induced for lung or if there is any strict model generated for lung. It is also possible to induce mitochondrial dysfunction by cigarette smoke, but we prefer to utilize KO model.

Thank you in advance!