In the rat 4-week oral toxicity study of drug A, such finding was seen in drug-treatment group without dose-dependent manner. I am not sure if the finding is drug-related or not, because the effect is not dose-proportionally, and seen in just a few animals.
Brian Lee
In the general situation, it is not known to occur spontaneously in rats. However, I couldn't state that specifically for your study since there are no details to examine.
Your statistical comparison would be the control group as well as historical information from prior organization experience. Not all toxic responses occur in a textbook dose-dependent manner. Real life can often be messier.
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