Izuru Miyawaki

3 Questions 1 Answers 0 Followers

Questions related from Izuru Miyawaki

Does anyone have transient increases in urinaly Kim-1 or Ngal in rat toxicity study?

We conducted 2-week dosing (i.v.) toxicity study of an antibiotic drug in rats (n=3). Time course urinary biomarker (Kim-1, Ngal) changes were checked in the study. As a results, transient...

25 September 2019 6,606 0 View

Does anyone know useful biomarkers of hepatic steatosis?

Generally, the echo analysis is clinically used for diagnosis of steatosis (fatty liver). I would like to know any other tools or biomarkers to detect steatosis in the preclinical or clinical study?

11 September 2013 4,970 2 View

Does anyone know whether the centrolobular vacuolation of hepatocytes occurs spontaneously in rats?

In the rat 4-week oral toxicity study of drug A, such finding was seen in drug-treatment group without dose-dependent manner. I am not sure if the finding is drug-related or not, because the...

20 August 2013 7,641 1 View