Would like to perform experiments in it's involvement in OA development.
Hi Natalia, I don't know of any specific MMP-14 inhibitor, but you could use MMP-14 specific antibodies to deplete your system.
Do you think that MMP-14 antibodies could be injected intraarticular and still serve the purpose of blocking this proteinase? Would this not cause immunological response?
http://zinc15.docking.org/genes/MMP14/observations/subsets/1nM/ will give you high affinity ligands, 1nM or better.
if you want the ones you can buy, there are only 2
http://zinc15.docking.org/genes/MMP14/observations/subsets/1nM/having/substance/subsets/for-sale/
Relaxing to 10nM you get a few more
http://zinc15.docking.org/genes/MMP14/observations/subsets/10nM/having/substance/subsets/for-sale/
Hope this is useful.
Good luck
John
Thank you John, although all proposed compounds are not selective for MMP-14. They bond to broad spectrum of other MMPs... As I will use this compounds in vivo I need them to be selective, otherwise I could not claim the effect through MMP-14
you may have trouble with that. I read that Britsh Biotechnology spent hundreds of millions of dollars, unsuccessfully, trying to find selective MMPx inhibitiors. The problem is that the binding sites are so similar, so the ligand would need to be very big. So there is a conflict between the molecule's size and the selectivity.
Good luck.
Thank you for your help! I don't know much about the topic yet. The only "claimed to be" selective inhibitor of MMP-14 seems to be DX-2400 from Dyax. I've contacted the company and waiting for replay.
I hope for us all that MMPs pharmacology will jump forward soon :)
Do you know any inhibitor that can bind to MMP14 at its extracellular site ?
- Badges
- Science topic
- Similar topics
- Chemistry
- Pharmacology