I know that phthalocyanines require metalation to undergo intersystem crossing, therefore they can be used as efficient photosensitizers in PDT.
I am wondering if the free-base phthalocyanine are really used in PDT?? and what is the benefit of these free-base molecules??
Yes, you can use free base Pc in PDT, see, e.g., Photochem. Photobiol.
2002, 75, 527-533. There are many reviews on Pc in PDT that would lead you there, for example: Molecules 2012, 17, 98-144 ...
In PDT, one of the most important parameter for photosensitizer is singlet oxygen production with high yield. In general, metalled phthalocyanine complexes have higher singlet oxygen production than their counterpart free phthalocyanine compounds. Especially, phthalocyanines metalled with zinc metal are generally used because zinc metal is not only harmless but also essential for human body.
i agree with Cem Göl and i want to add an information about singlet oxygen generation. You can not only use zinc metal but also use indium, galium, aluminium metals. In PDT, you should choose metallophthalocyanines if you obtained high singlet oxygen. May be you can use metal-free but you have to attach on pc core with heavy atom such as iodine, bromine groups.
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