Does anyone know how to deprotect gold nanoparticles stabilized with thiols?

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Vinay G Joshi

I think DTT treatment shall serve the purpose

Remco Verdoold

DTT at 1 M will deprotect, however, once the are deprotected they will aggregate! You very likely do not want this to happen. I would suggest a surfactant to protect the deprotected GNPs like: SDS, Triton-x100, Zonyl-FSN (very good fluor based surfactant).