I am not sure I have completly understood your question but concerning the changes and prodution of specific isomers in plants, I think they aregenerally controled by specific enzymes. On the contrary, some changings can occur during the extraction and storage process: these changing are mainly link to pressure, temperature and UV and are responsible in some cases of the racemization of the isomers or oxydation of sensible structures (ex. epoxy fonctions). To follow the quality of a preparation I think measurment (LC-MS) should be done every year. Now if you observe an alteration of the chemical composition of a particular extract and you want to know if it affects its value, I would guess that there is no general answer...
Components of essential oils change with genotype, plant ontogeny, environmental conditions, management etc. If you are interested in checking these factors you may read some of my chapters on rose-scented geranium, menthol mint, Tagetes minuta etc. Changes in isomers in response to the factors stated by you may be possible but I have not seen specific papers on the subject. Enantiomeric distribution of some essential oil components have been studied and literature search will yield good dividends.