Does anyone know a protocol more effective to induce muscle injury in mice through exercise?

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Andre Minari

good paper, but I think this protocol induced lower injuries...

thanks

Marco Machado

I think this paper could help you. http://jap.physiology.org/content/101/1/283.full-text.pdf+html

Protocol was very efficient for muscle damage.

Julien Gondin

Hi,

You can watch the video of the methodolgy used to induce (large) muscle damage

An in vivo rodent model of contraction-induced injury and non-invasive monitoring of recovery. Lovering RM, Roche JA, Goodall MH, Clark BB, McMillan A. J Vis Exp. 2011 May 11;(51). pii: 2782. doi: 10.3791/2782.

Richard L Lieber

I think it depends on the question you're asking. Downhill running is probably the most physiological method to induce injury but direct muscle deformation using a torque motor or linear motor is more controlled to study mechanics. It really depends whether you're asking muscle mechanism questions or exercise questions. Good luck!

Julien, can you send this video for me? i dont have acess to jove

Thanks