You could review this article - CANCER RESEARCH 48. 2880-2886, 1988 (in attachment). It will give you the information you need. The propagation efficiencies, growth patterns, histological appear ances, and roentgenographic demonstration of tumors derived from six continuous human pulmonary tumor cell lines (including NCI-H322) implanted intrathoracically (i.t.) and intrabronchially (i.b.) were compared with the conventional s.c. implantation method at three different tumor cell number inoculum.