Does anyone have experience with deep brain stimulation of a subject with depressive disorder, who was not pharmacoresistant?

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Lewis Alan Opler

I would recommend going to the person who serendipitously discovered that DBS treated depression, helen s mayberg, md

Article A "Special Conversation" About Science, Advocacy, and Mental...

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Michal Patarák

Thank you for your answer and for your recommendations.

Carl L Tishler

isnt there an ethical issue here? if someone is not pharacoresistant why even try dbs? why not add exercise, psychotherapy, yoga, magnetic stimulation, etc? carl tishler

Yes of course. But one of my female patient with chronic depression is asking for DBS treatment of her illness. Her disorder meets the criteria of depression (behaviorally), but I am conviced, it is primarily a peronality disorder. That is why several combinations of drug were not effective in her case. And that´s why I am asking. What if the depressive patient calls himself/herself for DBS? Is there any possibility that DBS would also help in comorbid depression?

Julio Torales

Hi Michal,

I did not found anything regarding the off label use of DBS in the treatment of a "non resistant" depression. Main reason for this could be the lack of data regarding the use of DBS in people that not meet criteria for resistant depression.

I will be in touch again if I find something.

Best regards,

Thank you! I will be grateful!

Thomas E Schlaepfer

Overall only about 200 patients have been treated worldwide, all with severe forms of TRD. This means that they did not respond to psychotherapy, pharmacotherapy and in most cases ECT. I am not aware of a single case of a patient treated with DBS who is not pharmacotherapy resistant. The overall efficacy has not been established yet. Please keep in mind that stereotactic neurosurgery is invasive and carries a 0.5-1% risk of hemorrhage.