I am trying to synthesis 1,2,4,5-tetrasubstituted imidazole with diketone, aldehyde, ary-triamine and ammonium acetate in acetic acid. But when I use acetic acid as solvent only one amine group is taking part in the imidazole and the other amine functions get protected by acetate.

I found acetic acid is the best for this cyclization than any other solvent.

I need all the three amine functions should be used for imidazole construction in a single molecule which means three imidazole in a core molecule.

So, could some of you please suggest me suggestions on this.

Thanks.