I always get pretty bad band distortion on restriction digests using BstYI or NdeI. The common factor is the CutSmart buffer. This doesn't happen to me with other enzymes. On the occasion when I cut with this buffer and extracted and precipitated the DNA the bands looked very nice, but this process is not always an option. Plus it doesn't make sense that NEB would have us use this buffer with so many enzymes if it messes up your gels. Still, I'm puzzled. Any ideas?