Plant secondary metabolites as thymol and carvacrol undergo glucuronidation and sulfation in liver, intestine and kidney. There are several isoforms of enzymes involved during this phase II of biotransformation.
Dear Vladimira
I dont think there is any direct report on query you arise on thymol and carvacrol. But it is confirmed both give strong antioxidant action and you may corelate your study with the simlar study by getting full paper of this reference.
Food Chem Toxicol. 2012 Mar;50(3-4):808-15. doi: 10.1016/j.fct.2011.11.018. Epub 2011 Nov 25.
Mangiferin glucuronidation: important hepatic modulation of antioxidant activity.
van der Merwe JD1, Joubert E, Manley M, de Beer D, Malherbe CJ, Gelderblom WC.
Dear Vladimira
You may get some information on metabolites products and major mecchanism of Thymol and Carvacrol in this attachments.
Thanking you
Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol
Rui-Hua Dong, Zhong-Ze Fang, Liang-Liang Zhu, Guang-Bo Ge, Ling Yang, and Ze-Yuan Liu
Xenobiotica, 2012; Early Online: 1–8
© 2012 Informa UK, Ltd.
ISSN 0049-8254 print/ISSN 1366-5928 online
DOI: 10.3109/00498254.2012.682614
Interesting question, carvacrol is the subject of my doctoral thesis
- Badges
- Science topic
- Similar topics
- Methodology
- Research Methodology
- Research Papers