Thanks for your attention,
I'd like to know whether all types endogenous RTases have a RNA binding domain or not.
A research published on Nature Structural & Molecular Biology, declearred that the telomerase has a RNA binding domain.
doi: doi:10.1038/nsmb.2819
Please help!
Surprisingly, the TERT region necessary and sufficient for telomerase RNA binding is completely separable from the reverse transcriptase motifs. The minimal Tetrahymena TERT RNA binding domain contains two sequence motifs with ciliate-specific conservation and one TERT motif with conservation across most of species.
See attached info for more info.
Good luck!
Surprisingly, the TERT region necessary and sufficient for telomerase RNA binding is completely separable from the reverse transcriptase motifs. The minimal Tetrahymena TERT RNA binding domain contains two sequence motifs with ciliate-specific conservation and one TERT motif with conservation across most of species.
See attached info for more info.
Good luck!
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