Dear All,
I need to determine the amount of solid triclosan identified on a plastic patch.
Our lab's protocol can only perform the determination in water. The triclosan load in the water ranges between 0.01 mg/mL and 0.1mg/mL
Given the slow dissolution rate of triclosan in water, even with constant stirring, that amount of solid triclosan is unlikely to be 50% dissolved within 5 days and 100% with 10 days.
Bakhtiyor Karimov (October 25, 2016) in a memo suggested adding acetone to the water in a 0.05% (0.5mL acetone in 1L of water).
Will a 0.05% acetone in water solvent significantly accelerate the degradation of triclosan over 10 days and will it cause a bias in our lab's measurements?
Thank you for helping
Frederic
Acetone doesn't degrade triclosan. 0.05 % acetone will minimally improve dissolution and solubility of triclosan. Perhaps dissolve the triclosan with pure acetone first and than dilute with water. Generally less than 10% acetone in water will change the solution properties of water very little. Since you don't mention which method of analysis you use no one can say if acetone interferes with analysis but at less tan 1 % it is unlikely.
Dear Henrik,
Thank you for your opinion. We have decided to conducted empirical titration of the amount of acetone mixed with water in relation to the saturation concentration of triclosan.
As for the degradation rate, we will repeat concentration measurements over time and find out the time needed to reduced concentration by 1% up to 50% with intermediate steps. We will then fit a mathematical model based on those suggested by various authors.
I don't see how we will resolve our problem otherwise.
Kind regards
Frederic
please check the below lins
Chapter Sediment Quality Guidelines
Article Pharmaceuticals of Emerging Concern in Aquatic Systems: Chem...
Data NOVO workshop finalno 14.09.2016.
Regards
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