Ceratonia siliqua ( family: Asteraceae )

Common name: Carob

Syzigium aromaticum, Cuminum cyminum and Zingiber officinal are one of the best herbs for Gastro-intestinal diseases like IBS.

Several papers have reported the plants containimg chemicals which are effective on Gastrointestinal disease. Some of them were given below:

* doi: 10.1016/j.foodres.2018.02.003

** https://doi.org/10.1016/j.jff.2015.09.064

*** https://doi.org/10.1016/j.bjp.2014.08.001

****http://dx.doi.org/10.1080/09735070.2013.11886456

*****https://doi.org/10.1016/j.jep.2019.112415

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Phytochemicals are non-nutritive bioactive secondary compounds abundantly found in fruits, grains, and vegetables.Consumption of phytochemicals may protect against chronic diseases like cardiovascular disease, neurodegenerative disease, and cancer. Multiple studies have assessed the chemoprotective effect of selected phytochemicals in GI cancer, offering support to their potential towards reducing the pathogenesis of the disease.

E.g.: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), detoxification enzymes, adenosine monophosphate activated protein kinase (AMPK), wingless-related integration site/β-catenin (wingless-related integration site (Wnt) β-catenin, cell apoptosis, phosphoinositide 3-kinases (PI3K)/ protein kinase B AKT/ mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK)

Many synthetic drugs are currently in use to treat IBD such as 5-aminosalicylic acid corticosteroids. However, they all have some drawbacks as long-term use result in many complications. These problems encourage us to look out for alternative medicine. Numerous in vitro and in vivo experiments showed that the plant-derived secondary metabolites including phenolic compounds, glucosinolates, alkaloids, terpenoids, oligosaccharides, and quinones could reduce permeability, ameliorate-related dysfunctions with promising results. In addition, many of them could modulate enzymatic activity, suppress the inflammatory transcriptional factors, ease oxidative stress, and reduce pro-inflammatory cytokines secretion.

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can you send some related articles?