I am trying to check whether inhibition/enhancing of PRMT5 expression have an effect on cell growth and looking for chemical compounds that act effectively in vivo.
I recently synthesized some curcuminoids building block which show potent anti parasitic activity. The biologist are trying to know the mechanism of the reaction, But it is observed from the study of our some colligues that enzyme arginase is involved in this mechanism. And the compound inhibit it. The activity will be finished in this running week. If You are interested of getting more information about this, please let me know.