Dear Jose,
In this article the authors claim that alpha-fetoprotein can be absorbed from GI tract into the blood (up to 11%) after per oral administration in an undigested form and travel to tumor sites carrying the non-covalently binded toxin (drug Aimpila) to destroy the tumor:
https://link.springer.com/article/10.1007/s10517-017-3956-y
Do you believe their results?
In the previous article of the same authors the absorbency was 0.1%:
file:///C:/Users/vpak/Downloads/otsenka-internalizatsii-afp-soderzhaschego-nekovalentnogo-kompleksa-aimpila-v-modeli-izolirovannogo-otrezka-tonkoy-kishki-krys.pdf
Thank you,
Vladimir N Pak, PhD
Dear Vladimir,
Since AFP is a protein, it undergoes proteolysis (digestion) first to peptides and further to free amino acids in GI tract by proteolytic enzymes. I think that toxin itself can be absorbed into the blood with no protein.
Dear Nurbubu,
In this case there is no sense in "drug Aimpila" (AFP+toxin non-covalent complex) because the toxin only is responsible for the demonstrated anti-cancer activity.
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