I'm currently working on visually identifying microplastics extracted from fish organs, and these are what I found. Do you think these spherical little things are microplastics? They are approximately 2.5 um in size and their presence is quite ubiquitous. If they are microplastics, are they pellets or granules? What are the differences between both?
When designing a study to evaluate the effects of a chemical or drug on an animal, it is important to consider the appropriate range of doses to test in order to identify the potential toxic effects of the substance. In general, it is recommended to test a range of doses that includes low, medium, and high doses, as well as a control group that receives no treatment.
In your case, you have already administered the highest dose (2000 mg/kg body weight) and have not observed any symptoms in the animal after 24 hours. Based on this information, you can consider the highest dose to be relatively safe and can move on to testing lower doses.
To decide on the two other doses for screening, you can consider the following options:
It is important to note that the specific doses to be tested will depend on the specific goals of the study and the resources available, and that it may be necessary to adjust the doses based on the results of the initial screening. It is also important to follow good laboratory practices and to handle the substances and animals carefully to ensure the safety and well-being of the animals and to minimize any potential risks to the environment.
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