patients who taking biology therapy to treat many autoimmune diseases ,have many immunological disturbances in their sera.
Dear Dr. Suha Abadullah Alfakhar
The reason for this increase in TNF-alpha levels is not fully understood, and the answer may vary between individuals. It has been suggested that inhibition of TNF-alpha by biological therapies may disrupt normal regulatory feedback loops, leading to an unintended increase in TNF-alpha production. It is important to note that the clinical significance of increased TNF-alpha concentrations during anti-TNF therapy is not completely clear and does not necessarily imply treatment failure. It could be result of paradoxical inflammation or paradoxical upregulation. Monitoring patients for both clinical symptoms and laboratory parameters is important, and adjustments to the treatment plan can be made based on individual patient response.
AB Bayazid
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